CCS Research
CCS Publications

2018-2019 / 20172016 2015 / 2014 / 2013 

  • Asslaber, D., Wacht, N., Leisch, M., Qi, Y., Maeding, N., Hufnagl, C., Jansko, B., Zaborsky, N., Villunger, A., Hartmann, T.N., Greil, R., and Egle, A. (2019). BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-kappaB Nuclear Translocation. Clin Cancer Res 25, 1901-1912.10.1158/1078-0432.CCR-18-1548

  • Bolger, G.T., Licollari, A., Tan, A., Greil, R., Vcelar, B., Greil-Ressler, S., Weiss, L., Schonlieb, C., Magnes, T., Radl, B., Majeed, M., and Sordillo, P.P. (2019). Pharmacokinetics of liposomal curcumin (Lipocurc) infusion: effect of co-medication in cancer patients and comparison with healthy individuals. Cancer Chemother Pharmacol 83, 265-275.10.1007/s00280-018-3730-5

  • Egle, A., Melchardt, T., Obrtlikova, P., Smolej, L., Kozak, T., Steurer, M., Andel, J., Burgstaller, S., Mikuskova, E., Gercheva, L., Nosslinger, T., Papajik, T., Ladicka, M., Girschikofsky, M., Hrubisko, M., Jager, U., Voskova, D., Pecherstorfer, M., Kralikova, E., Burcoveanu, C., Spasov, E., Petzer, A., Mihaylov, G., Raynov, J., Oexle, H., Zabernigg, A., Flochova, E., Palasthy, S., Stehlikova, O., Doubek, M., Altenhofer, P., Weiss, L., Magnes, T., Pleyer, L., Klingler, A., Mayer, J., and Greil, R. (2019). Rituximab maintenance overcomes the negative prognostic factor of obesity in CLL: Subgroup analysis of the international randomized AGMT CLL-8a mabtenance trial. Cancer Med 8, 1401-1405.10.1002/cam4.1980

  • Filipits, M., Dubsky, P., Rudas, M., Greil, R., Balic, M., Bago-Horvath, Z., Singer, C.F., Hlauschek, D., Brown, K., Bernhisel, R., Kronenwett, R., Lancaster, J.M., Fitzal, F., and Gnant, M. (2019). Prediction of Distant Recurrence Using EndoPredict Among Women with ER(+), HER2(-) Node-Positive and Node-Negative Breast Cancer Treated with Endocrine Therapy Only. Clin Cancer Res 25, 3865-3872.10.1158/1078-0432.CCR-19-0376

  • Gampenrieder, S.P., Peer, A., Weismann, C., Meissnitzer, M., Rinnerthaler, G., Webhofer, J., Westphal, T., Riedmann, M., Meissnitzer, T., Egger, H., Klaassen Federspiel, F., Reitsamer, R., Hauser-Kronberger, C., Stering, K., Hergan, K., Mlineritsch, B., and Greil, R. (2019). Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR). Breast Cancer Res 21, 19.10.1186/s13058-018-1091-y

  • Gnant, M., Pfeiler, G., Steger, G.G., Egle, D., Greil, R., Fitzal, F., Wette, V., Balic, M., Haslbauer, F., Melbinger-Zeinitzer, E., Bjelic-Radisic, V., Jakesz, R., Marth, C., Sevelda, P., Mlineritsch, B., Exner, R., Fesl, C., Frantal, S., Singer, C.F., Austrian, B., and Colorectal Cancer Study, G. (2019). Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol 20, 339-351.10.1016/S1470-2045(18)30862-3

  • Grassi, L., and Cabrele, C. (2019). Susceptibility of protein therapeutics to spontaneous chemical modifications by oxidation, cyclization, and elimination reactions. Amino Acids.10.1007/s00726-019-02787-2

  • Hinterholzer, A., Stanojlovic, V., Cabrele, C., and Schubert, M. (2019). Unambiguous identification of pyroglutamate in full-length biopharmaceutical monoclonal antibodies by NMR spectroscopy. Anal Chem.10.1021/acs.analchem.9b02513

  • Huemer, F., Melchardt, T., Jansko, B., Wahida, A., Jilg, S., Jost, P.J., Klieser, E., Steiger, K., Magnes, T., Pleyer, L., Greil-Ressler, S., Rass, C., Greil, R., and Egle, A. (2019a). Durable remissions with venetoclax monotherapy in secondary AML refractory to hypomethylating agents and high expression of BCL-2 and/or BIM. Eur J Haematol 102, 437-441.10.1111/ejh.13218

  • Huemer, F., Rinnerthaler, G., Lang, D., Hackl, H., Lamprecht, B., and Greil, R. (2019b). Association between antibiotics use and outcome in patients with NSCLC treated with immunotherapeutics. Ann Oncol 30, 652-653.10.1093/annonc/mdz021

  • Hung, R.J., Spitz, M.R., Houlston, R.S., Schwartz, A.G., Field, J.K., Ying, J., Li, Y., Han, Y., Ji, X., Chen, W., Wu, X., Gorlov, I.P., Na, J., de Andrade, M., Liu, G., Brhane, Y., Diao, N., Wenzlaff, A., Davies, M.P.A., Liloglou, T., Timofeeva, M., Muley, T., Rennert, H., Saliba, W., Ryan, B.M., Bowman, E., Barros-Dios, J.M., Perez-Rios, M., Morgenstern, H., Zienolddiny, S., Skaug, V., Ugolini, D., Bonassi, S., van der Heijden, E., Tardon, A., Bojesen, S.E., Landi, M.T., Johansson, M., Bickeboller, H., Arnold, S., Le Marchand, L., Melander, O., Andrew, A., Grankvist, K., Caporaso, N., Teare, M.D., Schabath, M.B., Aldrich, M.C., Kiemeney, L.A., Wichmann, H.E., Lazarus, P., Mayordomo, J., Neri, M., Haugen, A., Zhang, Z.F., Ruano-Ravina, A., Brenner, H., Harris, C.C., Orlow, I., Rennert, G., Risch, A., Brennan, P., Christiani, D.C., Amos, C.I., Yang, P., and Gorlova, O.Y. (2019). Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region. J Thorac Oncol 14, 1360-1369.10.1016/j.jtho.2019.04.008

  • Jiang, X., Finucane, H.K., Schumacher, F.R., Schmit, S.L., Tyrer, J.P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K.B., Dennis, J., Conti, D.V., Casey, G., Gaudet, M.M., Huyghe, J.R., Albanes, D., Aldrich, M.C., Andrew, A.S., Andrulis, I.L., Anton-Culver, H., Antoniou, A.C., Antonenkova, N.N., Arnold, S.M., Aronson, K.J., Arun, B.K., Bandera, E.V., Barkardottir, R.B., Barnes, D.R., Batra, J., Beckmann, M.W., Benitez, J., Benlloch, S., Berchuck, A., Berndt, S.I., Bickeboller, H., Bien, S.A., Blomqvist, C., Boccia, S., Bogdanova, N.V., Bojesen, S.E., Bolla, M.K., Brauch, H., Brenner, H., Brenton, J.D., Brook, M.N., Brunet, J., Brunnstrom, H., Buchanan, D.D., Burwinkel, B., Butzow, R., Cadoni, G., Caldes, T., Caligo, M.A., Campbell, I., Campbell, P.T., Cancel-Tassin, G., Cannon-Albright, L., Campa, D., Caporaso, N., Carvalho, A.L., Chan, A.T., Chang-Claude, J., Chanock, S.J., Chen, C., Christiani, D.C., Claes, K.B.M., Claessens, F., Clements, J., Collee, J.M., Correa, M.C., Couch, F.J., Cox, A., Cunningham, J.M., Cybulski, C., Czene, K., Daly, M.B., deFazio, A., Devilee, P., Diez, O., Gago-Dominguez, M., Donovan, J.L., Dork, T., Duell, E.J., Dunning, A.M., Dwek, M., Eccles, D.M., Edlund, C.K., Edwards, D.R.V., Ellberg, C., Evans, D.G., Fasching, P.A., Ferris, R.L., Liloglou, T., Figueiredo, J.C., Fletcher, O., Fortner, R.T., Fostira, F., Franceschi, S., Friedman, E., Gallinger, S.J., Ganz, P.A., Garber, J., Garcia-Saenz, J.A., Gayther, S.A., Giles, G.G., Godwin, A.K., Goldberg, M.S., Goldgar, D.E., Goode, E.L., Goodman, M.T., Goodman, G., Grankvist, K., Greene, M.H., Gronberg, H., Gronwald, J., Guenel, P., Hakansson, N., Hall, P., Hamann, U., Hamdy, F.C., Hamilton, R.J., Hampe, J., Haugen, A., Heitz, F., Herrero, R., Hillemanns, P., Hoffmeister, M., Hogdall, E., Hong, Y.C., Hopper, J.L., Houlston, R., Hulick, P.J., Hunter, D.J., Huntsman, D.G., Idos, G., Imyanitov, E.N., Ingles, S.A., Isaacs, C., Jakubowska, A., James, P., Jenkins, M.A., Johansson, M., Johansson, M., John, E.M., Joshi, A.D., Kaneva, R., Karlan, B.Y., Kelemen, L.E., Kuhl, T., Khaw, K.T., Khusnutdinova, E., Kibel, A.S., Kiemeney, L.A., Kim, J., Kjaer, S.K., Knight, J.A., Kogevinas, M., Kote-Jarai, Z., Koutros, S., Kristensen, V.N., Kupryjanczyk, J., Lacko, M., Lam, S., Lambrechts, D., Landi, M.T., Lazarus, P., Le, N.D., Lee, E., Lejbkowicz, F., Lenz, H.J., Leslie, G., Lessel, D., Lester, J., Levine, D.A., Li, L., Li, C.I., Lindblom, A., Lindor, N.M., Liu, G., Loupakis, F., Lubinski, J., Maehle, L., Maier, C., Mannermaa, A., Marchand, L.L., Margolin, S., May, T., McGuffog, L., Meindl, A., Middha, P., Miller, A., Milne, R.L., MacInnis, R.J., Modugno, F., Montagna, M., Moreno, V., Moysich, K.B., Mucci, L., Muir, K., Mulligan, A.M., Nathanson, K.L., Neal, D.E., Ness, A.R., Neuhausen, S.L., Nevanlinna, H., Newcomb, P.A., Newcomb, L.F., Nielsen, F.C., Nikitina-Zake, L., Nordestgaard, B.G., Nussbaum, R.L., Offit, K., Olah, E., Olama, A.A.A., Olopade, O.I., Olshan, A.F., Olsson, H., Osorio, A., Pandha, H., Park, J.Y., Pashayan, N., Parsons, M.T., Pejovic, T., Penney, K.L., Peters, W.H.M., Phelan, C.M., Phipps, A.I., Plaseska-Karanfilska, D., Pring, M., Prokofyeva, D., Radice, P., Stefansson, K., Ramus, S.J., Raskin, L., Rennert, G., Rennert, H.S., van Rensburg, E.J., Riggan, M.J., Risch, H.A., Risch, A., Roobol, M.J., Rosenstein, B.S., Rossing, M.A., De Ruyck, K., Saloustros, E., Sandler, D.P., Sawyer, E.J., Schabath, M.B., Schleutker, J., Schmidt, M.K., Setiawan, V.W., Shen, H., Siegel, E.M., Sieh, W., Singer, C.F., Slattery, M.L., Sorensen, K.D., Southey, M.C., Spurdle, A.B., Stanford, J.L., Stevens, V.L., Stintzing, S., Stone, J., Sundfeldt, K., Sutphen, R., Swerdlow, A.J., Tajara, E.H., Tangen, C.M., Tardon, A., Taylor, J.A., Teare, M.D., Teixeira, M.R., Terry, M.B., Terry, K.L., Thibodeau, S.N., Thomassen, M., Bjorge, L., Tischkowitz, M., Toland, A.E., Torres, D., Townsend, P.A., Travis, R.C., Tung, N., Tworoger, S.S., Ulrich, C.M., Usmani, N., Vachon, C.M., Van Nieuwenhuysen, E., Vega, A., Aguado-Barrera, M.E., Wang, Q., Webb, P.M., Weinberg, C.R., Weinstein, S., Weissler, M.C., Weitzel, J.N., West, C.M.L., White, E., Whittemore, A.S., Wichmann, H.E., Wiklund, F., Winqvist, R., Wolk, A., Woll, P., Woods, M., Wu, A.H., Wu, X., Yannoukakos, D., Zheng, W., Zienolddiny, S., Ziogas, A., Zorn, K.K., Lane, J.M., Saxena, R., Thomas, D., Hung, R.J., Diergaarde, B., McKay, J., Peters, U., Hsu, L., Garcia-Closas, M., Eeles, R.A., Chenevix-Trench, G., Brennan, P.J., Haiman, C.A., Simard, J., Easton, D.F., Gruber, S.B., Pharoah, P.D.P., Price, A.L., Pasaniuc, B., Amos, C.I., Kraft, P., and Lindstrom, S. (2019). Shared heritability and functional enrichment across six solid cancers. Nat Commun 10, 431.10.1038/s41467-018-08054-4

  • Klicznik, M.M., Morawski, P.A., Hollbacher, B., Varkhande, S.R., Motley, S.J., Kuri-Cervantes, L., Goodwin, E., Rosenblum, M.D., Long, S.A., Brachtl, G., Duhen, T., Betts, M.R., Campbell, D.J., and Gratz, I.K. (2019). Human CD4(+)CD103(+) cutaneous resident memory T cells are found in the circulation of healthy individuals. Sci Immunol 4.10.1126/sciimmunol.aav8995

  • Leisch, M., Egle, A., and Greil, R. (2019a). Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma. Future Oncol 15, 109-120.10.2217/fon-2018-0492

  • Leisch, M., Jansko, B., Zaborsky, N., Greil, R., and Pleyer, L. (2019b). Next Generation Sequencing in AML-On the Way to Becoming a New Standard for Treatment Initiation and/or Modulation? Cancers (Basel) 11.10.3390/cancers11020252

  • Li, Y., Xiao, X., Bosse, Y., Gorlova, O., Gorlov, I., Han, Y., Byun, J., Leighl, N., Johansen, J.S., Barnett, M., Chen, C., Goodman, G., Cox, A., Taylor, F., Woll, P., Wichmann, H.E., Manz, J., Muley, T., Risch, A., Rosenberger, A., Han, J., Siminovitch, K., Arnold, S.M., Haura, E.B., Bolca, C., Holcatova, I., Janout, V., Kontic, M., Lissowska, J., Mukeria, A., Ognjanovic, S., Orlowski, T.M., Scelo, G., Swiatkowska, B., Zaridze, D., Bakke, P., Skaug, V., Zienolddiny, S., Duell, E.J., Butler, L.M., Houlston, R., Artigas, M.S., Grankvist, K., Johansson, M., Shepherd, F.A., Marcus, M.W., Brunnstrom, H., Manjer, J., Melander, O., Muller, D.C., Overvad, K., Trichopoulou, A., Tumino, R., Liu, G., Bojesen, S.E., Wu, X., Le Marchand, L., Albanes, D., Bickeboller, H., Aldrich, M.C., Bush, W.S., Tardon, A., Rennert, G., Teare, M.D., Field, J.K., Kiemeney, L.A., Lazarus, P., Haugen, A., Lam, S., Schabath, M.B., Andrew, A.S., Bertazzi, P.A., Pesatori, A.C., Christiani, D.C., Caporaso, N., Johansson, M., McKay, J.D., Brennan, P., Hung, R.J., and Amos, C.I. (2019). Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development. Oncotarget 10, 1760-1774.10.18632/oncotarget.26678

  • Ludwig, H., Poenisch, W., Knop, S., Egle, A., Schreder, M., Lechner, D., Hajek, R., Gunsilius, E., Krenosz, K.J., Petzer, A., Weisel, K., Niederwieser, D., Einsele, H., Willenbacher, W., Melchardt, T., Greil, R., and Zojer, N. (2019a). Ixazomib-Thalidomide-Dexamethasone for induction therapy followed by Ixazomib maintenance treatment in patients with relapsed/refractory multiple myeloma. Br J Cancer.10.1038/s41416-019-0581-8

  • Ludwig, H., Ponisch, W., Knop, S., Egle, A., Hinke, A., Schreder, M., Lechner, D., Hajek, R., Gunsilius, E., Petzer, A., Weisel, K., Niederwieser, D., Einsele, H., Willenbacher, W., Rumpold, H., Pour, L., Jelinek, T., Krenosz, K.J., Meckl, A., Nolte, S., Melchardt, T., Greil, R., and Zojer, N. (2019b). Quality of life in patients with relapsed/refractory multiple myeloma during ixazomib-thalidomide-dexamethasone induction and ixazomib maintenance therapy and comparison to the general population. Leuk Lymphoma, 1-10.10.1080/10428194.2019.1666381

  • Magnes, T., Melchardt, T., Hufnagl, C., Weiss, L., Mittermair, C., Neureiter, D., Klieser, E., Rinnerthaler, G., Roesch, S., Gaggl, A., Greil, R., and Egle, A. (2019). Correction: The influence of FCGR2A and FCGR3A polymorphisms on the survival of patients with recurrent or metastatic squamous cell head and neck cancer treated with cetuximab. Pharmacogenomics J.10.1038/s41397-019-0073-5

  • Matikas, A., Foukakis, T., Moebus, V., Greil, R., Bengtsson, N.O., Steger, G.G., Untch, M., Johansson, H., Hellstrom, M., Malmstrom, P., Gnant, M., Loibl, S., and Bergh, J. (2019). Dose tailoring of adjuvant chemotherapy for breast cancer based on hematologic toxicities: further results from the prospective PANTHER study with focus on obese patients. Ann Oncol 30, 109-114.10.1093/annonc/mdy475

  • Moreno, C., Greil, R., Demirkan, F., Tedeschi, A., Anz, B., Larratt, L., Simkovic, M., Samoilova, O., Novak, J., Ben-Yehuda, D., Strugov, V., Gill, D., Gribben, J.G., Hsu, E., Lih, C.J., Zhou, C., Clow, F., James, D.F., Styles, L., and Flinn, I.W. (2019). Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 20, 43-56.10.1016/S1470-2045(18)30788-5

  • Muller, A., Gasch, J., Albring, K.F., Aberger, F., Nivarthi, H., Khemeri, M., Moriggl, R., and Friedrich, K.H. (2019). Interplay of transcription factors STAT3, STAT1 and AP-1 mediates activity of the matrix metallo-proteinase-1 promoter in colorectal carcinoma cells. Neoplasma 66, 357-366.10.4149/neo_2018_180731N560

  • Peer, E., Tesanovic, S., and Aberger, F. (2019). Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy. Cancers (Basel) 11.10.3390/cancers11040538

  • Posselt, G., Wiesauer, M., Chichirau, B.E., Engler, D., Krisch, L.M., Gadermaier, G., Briza, P., Schneider, S., Boccellato, F., Meyer, T.F., Hauser-Kronberger, C., Neureiter, D., Muller, A., and Wessler, S. (2019). Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis. Cell communication and signaling : CCS 17, 10.10.1186/s12964-019-0323-9

  • Prutsch, N., Gurnhofer, E., Suske, T., Liang, H.C., Schlederer, M., Roos, S., Wu, L.C., Simonitsch-Klupp, I., Alvarez-Hernandez, A., Kornauth, C., Leone, D.A., Svinka, J., Eferl, R., Limberger, T., Aufinger, A., Shirsath, N., Wolf, P., Hielscher, T., Aberger, F., Schmoellerl, J., Stoiber, D., Strobl, B., Jager, U., Staber, P.B., Grebien, F., Moriggl, R., Muller, M., Inghirami, G.G., Sanda, T., Look, A.T., Turner, S.D., Kenner, L., and Merkel, O. (2019). Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia 33, 696-709.10.1038/s41375-018-0239-1

  • Regl, C., Wohlschlager, T., Esser-Skala, W., Wagner, I., Samonig, M., Holzmann, J., and Huber, C.G. (2019). Dilute-and-shoot analysis of therapeutic monoclonal antibody variants in fermentation broth: a method capability study. Mabs-Austin 11, 569-582.10.1080/19420862.2018.1563034

  • Rinnerthaler, G., Gampenrieder, S.P., and Greil, R. (2019). HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer. International journal of molecular sciences 20.10.3390/ijms20051115

  • Rouschop, S.H., Karl, T., Risch, A., van Ewijk, P.A., Schrauwen-Hinderling, V.B., Opperhuizen, A., van Schooten, F.J., and Godschalk, R.W. (2019). Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet. J Lipid Res 60, 1250-1259.10.1194/jlr.M092593

  • Samadi, N., Klems, M., Heiden, D., Bauer, R., Kitzmuller, C., Weidmann, E., Ret, D., Ondracek, A.S., Duschl, A., Horejs-Hoeck, J., and Untersmayr, E. (2019). Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model. Allergy.10.1111/all.14030

  • Schlenk, R.F., Weber, D., Fiedler, W., Salih, H.R., Wulf, G., Salwender, H., Schroeder, T., Kindler, T., Lubbert, M., Wolf, D., Westermann, J., Kraemer, D., Gotze, K.S., Horst, H.A., Krauter, J., Girschikofsky, M., Ringhoffer, M., Sudhoff, T., Held, G., Derigs, H.G., Schroers, R., Greil, R., Griesshammer, M., Lange, E., Burchardt, A., Martens, U., Hertenstein, B., Marretta, L., Heuser, M., Thol, F., Gaidzik, V.I., Herr, W., Krzykalla, J., Benner, A., Dohner, K., Ganser, A., Paschka, P., Dohner, H., and German-Austrian, A.M.L.S.G. (2019). Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD. Blood 133, 840-851.10.1182/blood-2018-08-869453

  • Schweida, D., Barraud, P., Regl, C., Loughlin, F.E., Huber, C.G., Cabrele, C., and Schubert, M. (2019). The NMR signature of gluconoylation: a frequent N-terminal modification of isotope-labeled proteins. J Biomol Nmr 73, 71-79.10.1007/s10858-019-00228-6

  • Sgouras, D., Tegtmeyer, N., and Wessler, S. (2019). Activity and Functional Importance of Helicobacter pylori Virulence Factors. Advances in experimental medicine and biology.10.1007/5584_2019_358

  • Spicka, I., Ocio, E.M., Oakervee, H.E., Greil, R., Banh, R.H., Huang, S.Y., D'Rozario, J.M., Dimopoulos, M.A., Martinez, S., Extremera, S., Kahatt, C., Alfaro, V., Carella, A.M., Meuleman, N., Hajek, R., Symeonidis, A., Min, C.K., Cannell, P., Ludwig, H., Sonneveld, P., and Mateos, M.V. (2019). Randomized phase III study (ADMYRE) of plitidepsin in combination with dexamethasone vs. dexamethasone alone in patients with relapsed/refractory multiple myeloma. Ann Hematol 98, 2139-2150.10.1007/s00277-019-03739-2

  • Wildner, S., Huber, S., Regl, C., Huber, C.G., Lohrig, U., and Gadermaier, G. (2019). Aptamers as quality control tool for production, storage and biosimilarity of the anti-CD20 biopharmaceutical rituximab. Scientific reports 9.ARTN 1111 10.1038/s41598-018-37624-1

  • Willer, J., Johrer, K., Greil, R., Zidorn, C., and Cicek, S.S. (2019). Cytotoxic Properties of Damiana (Turnera diffusa) Extracts and Constituents and A Validated Quantitative UHPLC-DAD Assay. Molecules 24.10.3390/molecules24050855

  • Zaborsky, N., Gassner, F.J., Hopner, J.P., Schubert, M., Hebenstreit, D., Stark, R., Asslaber, D., Steiner, M., Geisberger, R., Greil, R., and Egle, A. (2019). Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development. Leukemia 33, 957-968.10.1038/s41375-018-0260-4

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  • Rosenberger, A., Hung, R.J., Christiani, D.C., Caporaso, N.E., Liu, G., Bojesen, S.E., Le Marchand, L., Haiman, C.A., Albanes, D., Aldrich, M.C., Tardon, A., Fernandez-Tardon, G., Rennert, G., Field, J.K., Kiemeney, B., Lazarus, P., Haugen, A., Zienolddiny, S., Lam, S., Schabath, M.B., Andrew, A.S., Brunnsstom, H., Goodman, G.E., Doherty, J.A., Chen, C., Teare, M.D., Wichmann, H.E., Manz, J., Risch, A., Muley, T.R., Johansson, M., Brennan, P., Landi, M.T., Amos, C.I., Pesch, B., Johnen, G., Bruning, T., Bickeboller, H., and Gomolka, M. (2018). Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners. Int Arch Occup Environ Health.10.1007/s00420-018-1334-3

  • Schlick, K., Magnes, T., Ratzinger, L., Jaud, B., Weiss, L., Melchardt, T., Greil, R., and Egle, A. (2018). Novel models for prediction of benefit and toxicity with FOLFIRINOX treatment of pancreatic cancer using clinically available parameters. PloS one 13, e0206688.10.1371/journal.pone.0206688

  • Schubert, M., Hackl, H., Gassner, F.J., Greil, R., and Geisberger, R. (2018). Investigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia. PloS one 13, e0208753.10.1371/journal.pone.0208753

  • Siemer, S., Hahlbrock, A., Vallet, C., McClements, D.J., Balszuweit, J., Voskuhl, J., Docter, D., Wessler, S., Knauer, S.K., Westmeier, D., and Stauber, R.H. (2018). Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study. NPJ science of food 2, 22.10.1038/s41538-018-0030-8

  • Skala, W., Wohlschlager, T., Senn, S., Huber, G.E., and Huber, C.G. (2018). MoFi: A Software Tool for Annotating Glycoprotein Mass Spectra by Integrating Hybrid Data from the Intact Protein and Glycopeptide Level. Anal Chem 90, 5728-5736.10.1021/acs.analchem.8b00019

  • Sternberg, C., Gruber, W., Eberl, M., Tesanovic, S., Stadler, M., Elmer, D.P., Schlederer, M., Grund, S., Roos, S., Wolff, F., Kaur, S., Mangelberger, D., Lehrach, H., Hache, H., Wierling, C., Laimer, J., Lackner, P., Wiederstein, M., Kasper, M., Risch, A., Petzelbauer, P., Moriggl, R., Kenner, L., and Aberger, F. (2018). Synergistic Cross-Talk of Hedgehog and Interleukin-6 Signaling Drives Growth of Basal Cell Carcinoma. Int J Cancer.10.1002/ijc.31724

  • Stock, L.G., Wildner, S., Regl, C., Gadermaier, G., Huber, C.G., and Stutz, H. (2018). Monitoring of Deamidation and Lanthionine Formation in Recombinant Mugwort Allergen by Capillary Zone Electrophoresis (CZE)-UV and Transient Capillary Isotachophoresis-CZE-Electrospray lonization-TOF-MS. Anal Chem 90, 11933-11940.10.1021/acs.analchem.8b02328

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  • Westphal, T., Rinnerthaler, G., Gampenrieder, S.P., Niebauer, J., Thaler, J., Pfob, M., Fuchs, D., Riedmann, M., Mayr, B., Reich, B., Melchardt, T., Mlineritsch, B., Pleyer, L., and Greil, R. (2018b). Supervised versus autonomous exercise training in breast cancer patients: A multicenter randomized clinical trial. Cancer Med 7, 5962-5972.10.1002/cam4.1851

  • Wohlschlager, T., Regl, C., and Huber, C.G. (2018a). Monitoring of Oxidation in Biopharmaceuticals with Top-to-Bottom High Performance Liquid Chromatography-Mass Spectrometry Methodologies: A Critical Check. Lc Gc Eur 31, 326-331

  • Wohlschlager, T., Scheffler, K., Forstenlehner, I.C., Skala, W., Senn, S., Damoc, E., Holzmann, J., and Huber, C.G. (2018b). Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals. Nature Communications 9.ARTN 1713 10.1038/s41467-018-04061-7

  • Zauner, F.B., Dall, E., Regl, C., Grassi, L., Huber, C.G., Cabrele, C., and Brandstetter, H. (2018). Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation. Plant Cell 30, 686-699.10.1105/tpc.17.00963

Translational cancer research at CCS

Bench-to-bedside and bedside-to-bench work

The scientific strategy and conceptual organization of CCS allows both the validation of basic research findings in clinical settings (bench to bedside) and the detailed molecular analysis of clinical observations in predictive in vitro and in vivo model systems (bedside to bench). This bidirectional research strategy accelerates the discovery of novel and innovative therapeutic approaches for personalized cancer therapy. 

Funding & Support

Cancer Cluster Salzburg at SCRI

3rd Medical Department

Paracelsus Medical University Clinics Salzburg

Müllner Hauptstrasse 48, 5020 Salzburg, Austria

Email: ccs@sbg.ac.at

Cancer Cluster Salzburg at PLUS

Department of Biosciences

University of Salzburg

Hellbrunner Strasse 34, 5020 Salzburg, Austria

Email: ccs@sbg.ac.at