CCS Research
CCS Publications
  • Althammer, M., Blochl, C., Reischl, R., Huber, C.G., and Tenhaken, R. (2020). Phosphoglucomutase Is Not the Target for Galactose Toxicity in Plants. Front Plant Sci 11, 167.10.3389/fpls.2020.00167

  • Barraco, F., Greil, R., Herbrecht, R., Schmidt, B., Reiter, A., Willenbacher, W., Raymakers, R., Liersch, R., Wroclawska, M., Pack, R., Burock, K., Karumanchi, D., and Gisslinger, H. (2020). Real-world non-interventional long-term post-authorisation safety study of ruxolitinib in myelofibrosis. Br J Haematol.10.1111/bjh.16729

  • Bekric, D., Neureiter, D., Ritter, M., Jakab, M., Gaisberger, M., Pichler, M., Kiesslich, T., and Mayr, C. (2020). Long Non-Coding RNAs in Biliary Tract Cancer-An Up-to-Date Review. J Clin Med 9.10.3390/jcm9041200

  • Bernegger, S., Brunner, C., Vizovisek, M., Fonovic, M., Cuciniello, G., Giordano, F., Stanojlovic, V., Jarzab, M., Simister, P., Feller, S.M., Obermeyer, G., Posselt, G., Turk, B., Cabrele, C., Schneider, G., and Wessler, S. (2020). A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding. Sci Rep 10, 10563.10.1038/s41598-020-67578-2

  • Boraschi, D., Alijagic, A., Auguste, M., Barbero, F., Ferrari, E., Hernadi, S., Mayall, C., Michelini, S., Navarro Pacheco, N.I., Prinelli, A., Swart, E., Swartzwelter, B.J., Bastus, N.G., Canesi, L., Drobne, D., Duschl, A., Ewart, M.A., Horejs-Hoeck, J., Italiani, P., Kemmerling, B., Kille, P., Prochazkova, P., Puntes, V.F., Spurgeon, D.J., Svendsen, C., Wilde, C.J., and Pinsino, A. (2020). Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species. Small 16, e2000598.10.1002/smll.202000598

  • Bosse, Y., Li, Z., Xia, J., Manem, V., Carreras-Torres, R., Gabriel, A., Gaudreault, N., Albanes, D., Aldrich, M.C., Andrew, A., Arnold, S., Bickeboller, H., Bojesen, S.E., Brennan, P., Brunnstrom, H., Caporaso, N., Chen, C., Christiani, D.C., Field, J.K., Goodman, G., Grankvist, K., Houlston, R., Johansson, M., Johansson, M., Kiemeney, L.A., Lam, S., Landi, M.T., Lazarus, P., Le Marchand, L., Liu, G., Melander, O., Rennert, G., Risch, A., Rosenberg, S.M., Schabath, M.B., Shete, S., Song, Z., Stevens, V.L., Tardon, A., Wichmann, H.E., Woll, P., Zienolddiny, S., Obeidat, M., Timens, W., Hung, R.J., Joubert, P., Amos, C.I., and McKay, J.D. (2020). Transcriptome-wide association study reveals candidate causal genes for lung cancer. Int J Cancer 146, 1862-1878.10.1002/ijc.32771

  • Dai, J., Huang, M., Amos, C.I., Hung, R.J., Tardon, A., Andrew, A., Chen, C., Christiani, D.C., Albanes, D., Rennert, G., Fan, J., Goodman, G., Liu, G., Field, J.K., Grankvist, K., Kiemeney, L.A., Le Marchand, L., Schabath, M.B., Johansson, M., Aldrich, M.C., Johansson, M., Caporaso, N., Lazarus, P., Lam, S., Bojesen, S.E., Arnold, S., Landi, M.T., Risch, A., Wichmann, H.E., Bickeboller, H., Brennan, P., Shete, S., Melander, O., Brunnstrom, H., Zienolddiny, S., Woll, P., Stevens, V., Hu, Z., and Shen, H. (2020). Genome-wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk. Int J Cancer 146, 2855-2864.10.1002/ijc.32698

  • Dubsky, P.C., Singer, C.F., Egle, D., Wette, V., Petru, E., Balic, M., Pichler, A., Greil, R., Petzer, A.L., Bago-Horvath, Z., Fesl, C., Meek, S.M., Kronenwett, R., Rudas, M., Gnant, M., Filipits, M., Austrian, B., and Colorectal Cancer Study, G. (2020). The EndoPredict score predicts response to neoadjuvant chemotherapy and neoendocrine therapy in hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer patients from the ABCSG-34 trial. Eur J Cancer 134, 99-106.10.1016/j.ejca.2020.04.020

  • Esser-Skala, W., Segl, M., Wohlschlager, T., Reisinger, V., Holzmann, J., and Huber, C.G. (2020a). Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins. Anal Bioanal Chem.10.1007/s00216-020-02796-1

  • Esser-Skala, W., Wohlschlager, T., Regl, C., and Huber, C.G. (2020b). A Simple Strategy to Eliminate Hexosylation Bias in the Relative Quantification of N-Glycosylation in Biopharmaceuticals. Angew Chem Int Ed Engl.10.1002/anie.202002147

  • Gassner, F.J., Zaborsky, N., Feldbacher, D., Greil, R., and Geisberger, R. (2020). RNA Editing Alters miRNA Function in Chronic Lymphocytic Leukemia. Cancers (Basel) 12.10.3390/cancers12051159

  • Gratz, I.K., and Campbell, D.J. (2020). Resident memory T cells show that it is never too late to change your ways. Nat Immunol 21, 359-360.10.1038/s41590-020-0637-1

  • Grund-Groschke, S., Ortner, D., Szenes-Nagy, A.B., Zaborsky, N., Weiss, R., Neureiter, D., Wipplinger, M., Risch, A., Hammerl, P., Greil, R., Sibilia, M., Gratz, I.K., Stoitzner, P., and Aberger, F. (2020). Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity. Mol Oncol.10.1002/1878-0261.12758

  • Gutjahr, J.C., Bayer, E., Yu, X., Laufer, J.M., Hopner, J.P., Tesanovic, S., Harzschel, A., Auer, G., Riess, T., Salmhofer, A., Szenes, E., Haslauer, T., Durand-Onayli, V., Ramspacher, A., Pennisi, S.P., Artinger, M., Zaborsky, N., Chigaev, A., Aberger, F., Neureiter, D., Pleyer, L., Legler, D.F., Orian-Rousseau, V., Greil, R., and Hartmann, T.N. (2020). CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity. Haematologica.10.3324/haematol.2019.231944

  • Heimesaat, M.M., Schmidt, A.M., Mousavi, S., Escher, U., Tegtmeyer, N., Wessler, S., Gadermaier, G., Briza, P., Hofreuter, D., Bereswill, S., and Backert, S. (2020). Peptidase PepP is a novel virulence factor of Campylobacter jejuni contributing to murine campylobacteriosis. Gut Microbes, 1-15.10.1080/19490976.2020.1770017

  • Hinterholzer, A., Stanojlovic, V., Regl, C., Huber, C.G., Cabrele, C., and Schubert, M. (2020). Identification and Quantification of Oxidation Products in Full-Length Biotherapeutic Antibodies by NMR Spectroscopy. Anal Chem 92, 9666-9673.10.1021/acs.analchem.0c00965

  • Huemer, F., Leisch, M., Geisberger, R., Melchardt, T., Rinnerthaler, G., Zaborsky, N., and Greil, R. (2020a). Combination Strategies for Immune-Checkpoint Blockade and Response Prediction by Artificial Intelligence. Int J Mol Sci 21.10.3390/ijms21082856

  • Huemer, F., Weiss, L., Regitnig, P., Winder, T., Hartmann, B., Thaler, J., Piringer, G., Schmitt, C.A., Eisterer, W., Ganzer, H., Wustner, A., Andel, J., Jagdt, B., Ulmer, H., Greil, R., and Woll, E. (2020b). Local and Central Evaluation of HER2 Positivity and Clinical Outcome in Advanced Gastric and Gastroesophageal Cancer-Results from the AGMT GASTRIC-5 Registry. J Clin Med 9.10.3390/jcm9040935

  • Hufnagl, C., Leisch, M., Weiss, L., Melchardt, T., Moik, M., Asslaber, D., Roland, G., Steininger, P., Meissnitzer, T., Neureiter, D., Greil, R., and Egle, A. (2020). Evaluation of circulating cell-free DNA as a molecular monitoring tool in patients with metastatic cancer. Oncol Lett 19, 1551-1558.10.3892/ol.2019.11192

  • Ji, X., Mukherjee, S., Landi, M.T., Bosse, Y., Joubert, P., Zhu, D., Gorlov, I., Xiao, X., Han, Y., Gorlova, O., Hung, R.J., Brhane, Y., Carreras-Torres, R., Christiani, D.C., Caporaso, N., Johansson, M., Liu, G., Bojesen, S.E., Le Marchand, L., Albanes, D., Bickeboller, H., Aldrich, M.C., Bush, W.S., Tardon, A., Rennert, G., Chen, C., Byun, J., Dragnev, K.H., Field, J.K., Kiemeney, L.F., Lazarus, P., Zienolddiny, S., Lam, S., Schabath, M.B., Andrew, A.S., Bertazzi, P.A., Pesatori, A.C., Diao, N., Su, L., Song, L., Zhang, R., Leighl, N., Johansen, J.S., Mellemgaard, A., Saliba, W., Haiman, C., Wilkens, L., Fernandez-Somoano, A., Fernandez-Tardon, G., Heijden, E., Kim, J.H., Davies, M.P.A., Marcus, M.W., Brunnstrom, H., Manjer, J., Melander, O., Muller, D.C., Overvad, K., Trichopoulou, A., Tumino, R., Goodman, G.E., Cox, A., Taylor, F., Woll, P., Wichmann, E., Muley, T., Risch, A., Rosenberger, A., Grankvist, K., Johansson, M., Shepherd, F., Tsao, M.S., Arnold, S.M., Haura, E.B., Bolca, C., Holcatova, I., Janout, V., Kontic, M., Lissowska, J., Mukeria, A., Ognjanovic, S., Orlowski, T.M., Scelo, G., Swiatkowska, B., Zaridze, D., Bakke, P., Skaug, V., Butler, L.M., Offit, K., Srinivasan, P., Bandlamudi, C., Hellmann, M.D., Solit, D.B., Robson, M.E., Rudin, C.M., Stadler, Z.K., Taylor, B.S., Berger, M.F., Houlston, R., McLaughlin, J., Stevens, V., Nickle, D.C., Obeidat, M., Timens, W., Artigas, M.S., Shete, S., Brenner, H., Chanock, S., Brennan, P., McKay, J.D., and Amos, C.I. (2020). Protein-altering germline mutations implicate novel genes related to lung cancer development. Nat Commun 11, 2220.10.1038/s41467-020-15905-6

  • Kim-Wanner, S.Z., Assenov, Y., Nair, M.B., Weichenhan, D., Benner, A., Becker, N., Landwehr, K., Kuner, R., Sultmann, H., Esteller, M., Koch, I., Lindner, M., Meister, M., Thomas, M., Bieg, M., Klingmuller, U., Schlesner, M., Warth, A., Brors, B., Seifried, E., Bonig, H., Plass, C., Risch, A., and Muley, T. (2020). Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenocarcinoma Reveals Predictive Aberrant Methylation in the Promoter Region of the Long Noncoding RNA PLUT: An Exploratory Study. J Thorac Oncol 15, 1338-1350.10.1016/j.jtho.2020.03.023

  • Klicznik, M.M., Benedetti, A., Gail, L.M., Varkhande, S.R., Holly, R., Laimer, M., Stoecklinger, A., Sir, A., Reitsamer, R., Neuper, T., Horejs-Hoeck, J., Rosenblum, M.D., Campbell, D.J., Murauer, E.M., and Gratz, I.K. (2020). A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin. Sci Rep 10, 11164.10.1038/s41598-020-67430-7

  • Korotchenko, E., Moya, R., Scheiblhofer, S., Joubert, I.A., Horejs-Hoeck, J., Hauser, M., Calzada, D., Iraola, V., Carnes, J., and Weiss, R. (2020a). Laser-facilitated epicutaneous immunotherapy with depigmented house dust mite extract alleviates allergic responses in a mouse model of allergic lung inflammation. Allergy 75, 1217-1228.10.1111/all.14164

  • Korotchenko, E., Schiessl, V., Scheiblhofer, S., Schubert, M., Dall, E., Joubert, I.A., Strandt, H., Neuper, T., Sarajlic, M., Bauer, R., Geppert, M., Joedicke, D., Wildner, S., Schaller, S., Winkler, S., Gadermaier, G., Horejs-Hoeck, J., and Weiss, R. (2020b). Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma. Allergy.10.1111/all.14481

  • Leisch, M., Greil, R., and Pleyer, L. (2020). IDO in MDS/AML disease progression and its role in resistance to azacitidine: a potential new drug target? Br J Haematol.10.1111/bjh.16710

  • Ludwig, H., Ponisch, W., Knop, S., Egle, A., Hinke, A., Schreder, M., Lechner, D., Hajek, R., Gunsilius, E., Petzer, A., Weisel, K., Niederwieser, D., Einsele, H., Willenbacher, W., Rumpold, H., Pour, L., Jelinek, T., Krenosz, K.J., Meckl, A., Nolte, S., Melchardt, T., Greil, R., and Zojer, N. (2020). Quality of life in patients with relapsed/refractory multiple myeloma during ixazomib-thalidomide-dexamethasone induction and ixazomib maintenance therapy and comparison to the general population. Leuk Lymphoma 61, 377-386.10.1080/10428194.2019.1666381

  • Murthy, R.K., Loi, S., Okines, A., Paplomata, E., Hamilton, E., Hurvitz, S.A., Lin, N.U., Borges, V., Abramson, V., Anders, C., Bedard, P.L., Oliveira, M., Jakobsen, E., Bachelot, T., Shachar, S.S., Muller, V., Braga, S., Duhoux, F.P., Greil, R., Cameron, D., Carey, L.A., Curigliano, G., Gelmon, K., Hortobagyi, G., Krop, I., Loibl, S., Pegram, M., Slamon, D., Palanca-Wessels, M.C., Walker, L., Feng, W., and Winer, E.P. (2020). Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer. N Engl J Med 382, 597-609.10.1056/NEJMoa1914609

  • Neuper, T., Frauenlob, T., Sarajlic, M., Posselt, G., Wessler, S., and Horejs-Hoeck, J. (2020a). TLR2, TLR4 and TLR10 Shape the Cytokine and Chemokine Release of H. pylori-Infected Human DCs. Int J Mol Sci 21.10.3390/ijms21113897

  • Neuper, T., Neureiter, D., Sarajlic, M., Strandt, H., Bauer, R., Schwarz, H., Suchanek, P., Korotchenko, E., Dillon, S.R., Hammerl, P., Stoecklinger, A., Weiss, R., and Horejs-Hoeck, J. (2020b). IL-31 transgenic mice show reduced allergen-induced lung inflammation. Eur J Immunol.10.1002/eji.202048547

  • Neureiter, D., Mayr, C., and Kiesslich, T. (2020a). How do we choose the appropriate chemotherapeutic agents for biliary tract cancer? Expert Opin Pharmacother 21, 243-245.10.1080/14656566.2019.1705280

  • Neureiter, D., Mayr, C., Winkelmann, P., Neumayer, B., Klieser, E., Wagner, A., Hufnagl, C., Emmanuel, K., Holzinger, J., Koch, O., Kiesslich, T., and Varga, M. (2020b). Expression of the microRNA-200 Family, microRNA-205, and Markers of Epithelial-Mesenchymal Transition as Predictors for Endoscopic Submucosal Dissection over Esophagectomy in Esophageal Adenocarcinoma: A Single-Center Experience. Cells 9.10.3390/cells9020486

  • Oberhuber, M., Pecoraro, M., Rusz, M., Oberhuber, G., Wieselberg, M., Haslinger, P., Gurnhofer, E., Schlederer, M., Limberger, T., Lagger, S., Pencik, J., Kodajova, P., Hogler, S., Stockmaier, G., Grund-Groschke, S., Aberger, F., Bolis, M., Theurillat, J.P., Wiebringhaus, R., Weiss, T., Haitel, A., Brehme, M., Wadsak, W., Griss, J., Mohr, T., Hofer, A., Jager, A., Pollheimer, J., Egger, G., Koellensperger, G., Mann, M., Hantusch, B., and Kenner, L. (2020). STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer. Mol Syst Biol 16, e9247.10.15252/msb.20199247

  • Ozsoy, M., Zimmermann, F.A., Feichtinger, R.G., Mayr, J.A., Kofler, B., Neureiter, D., Klieser, E., Schutz, S., Weghuber, D., and Schneider, A.M. (2020). Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa. Exp Gerontol 135, 110924.10.1016/j.exger.2020.110924

  • Papakonstantinou, A., Hedayati, E., Hellstrom, M., Johansson, H., Gnant, M., Steger, G., Greil, R., Untch, M., Moebus, V., Loibl, S., Foukakis, T., Bergh, J., and Matikas, A. (2020a). Neutropenic complications in the PANTHER phase III study of adjuvant tailored dose-dense chemotherapy in early breast cancer. Acta Oncol 59, 75-81.10.1080/0284186X.2019.1670353

  • Papakonstantinou, A., Matikas, A., Bengtsson, N.O., Malmstrom, P., Hedayati, E., Steger, G., Untch, M., Hubbert, L., Johansson, H., Hellstrom, M., Gnant, M., Loibl, S., Greil, R., Moebus, V., Foukakis, T., and Bergh, J. (2020b). Efficacy and safety of tailored and dose-dense adjuvant chemotherapy and trastuzumab for resected HER2-positive breast cancer: Results from the phase 3 PANTHER trial. Cancer 126, 1175-1182.10.1002/cncr.32653

  • Petzer, A.L., Sperr, W.R., Buxhofer-Ausch, V., Sliwa, T., Schmidt, S., Greil, R., Wolfler, A., Pichler, P., Dormann, C., Burgstaller, S., Tinchon, C., Lang, A., Goebel, F., Uthman, S., Muenchmeier, N., and Valent, P. (2020). A multicenter retrospective evaluation of Chronic Myeloid Leukemia (CML) therapy in Austria assessing the impact of early treatment response on patient outcomes in a real-life setting : R-EFECT study. Wien Klin Wochenschr.10.1007/s00508-020-01690-1

  • Posch, A., Hofer-Zeni, S., Klieser, E., Primavesi, F., Naderlinger, E., Brandstetter, A., Filipits, M., Urbas, R., Swiercynski, S., Jager, T., Winkelmann, P., Kiesslich, T., Lu, L., Neureiter, D., Stattner, S., and Holzmann, K. (2020). Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns. Cancers (Basel) 12.10.3390/cancers12061625

  • Primavesi, F., Andreasi, V., Hoogwater, F.J.H., Partelli, S., Wiese, D., Heidsma, C., Cardini, B., Klieser, E., Marsoner, K., Froschl, U., Thalhammer, S., Fischer, I., Gobel, G., Hauer, A., Kiesslich, T., Ellmerer, P., Klug, R., Neureiter, D., Wundsam, H., Sellner, F., Kornprat, P., Fugger, R., Ofner, D., Nieveen van Dijkum, E.J.M., Bartsch, D.K., de Kleine, R.H.J., Falconi, M., and Stattner, S. (2020). A Preoperative Clinical Risk Score Including C-Reactive Protein Predicts Histological Tumor Characteristics and Patient Survival after Surgery for Sporadic Non-Functional Pancreatic Neuroendocrine Neoplasms: An International Multicenter Cohort Study. Cancers (Basel) 12.10.3390/cancers12051235

  • Prutsch, N., Gurnhofer, E., Suske, T., Liang, H.C., Schlederer, M., Roos, S., Wu, L.C., Simonitsch-Klupp, I., Alvarez-Hernandez, A., Kornauth, C., Leone, D.A., Svinka, J., Eferl, R., Limberger, T., Aufinger, A., Shirsath, N., Wolf, P., Hielscher, T., Sternberg, C., Aberger, F., Schmoellerl, J., Stoiber, D., Strobl, B., Jager, U., Staber, P.B., Grebien, F., Moriggl, R., Muller, M., Inghirami, G.G., Sanda, T., Look, A.T., Turner, S.D., Kenner, L., and Merkel, O. (2020). Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia.10.1038/s41375-020-0968-9

  • Reinders, J., Altenbuchinger, M., Limm, K., Schwarzfischer, P., Scheidt, T., Strasser, L., Richter, J., Szczepanowski, M., Huber, C.G., Klapper, W., Spang, R., and Oefner, P.J. (2020). Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue. Sci Rep 10, 7876.10.1038/s41598-020-64212-z

  • Riedl, J.M., Posch, F., Prager, G., Eisterer, W., Oehler, L., Sliwa, T., Wilthoner, K., Petzer, A., Pichler, P., Hubmann, E., Winder, T., Burgstaller, S., Korger, M., Andel, J., Greil, R., Neumann, H.J., Pecherstorfer, M., Philipp-Abbrederis, K., Djanani, A., Gruenberger, B., Laengle, F., Woll, E., and Gerger, A. (2020). The AST/ALT (De Ritis) ratio predicts clinical outcome in patients with pancreatic cancer treated with first-line nab-paclitaxel and gemcitabine: post hoc analysis of an Austrian multicenter, noninterventional study. Ther Adv Med Oncol 12, 1758835919900872.10.1177/1758835919900872

  • Rinnerthaler, G., Gampenrieder, S.P., Hackl, H., Steiner, M., Monzo-Fuentes, C., Melchardt, T., Magnes, T., Huemer, F., Westphal, T., Hufnagl, C., Hauser-Kronberger, C., Egle, A., and Greil, R. (2020). Low Expression of miR-20a-5p Predicts Benefit to Bevacizumab in Metastatic Breast Cancer Patients Treated within the TANIA Phase III Trial. J Clin Med 9.10.3390/jcm9061663

  • Samadi, N., Klems, M., Heiden, D., Bauer, R., Kitzmuller, C., Weidmann, E., Ret, D., Ondracek, A.S., Duschl, A., Horejs-Hoeck, J., and Untersmayr, E. (2020). Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model. Allergy 75, 412-422.10.1111/all.14030

  • Samonig, L., Loipetzberger, A., Blochl, C., Rurik, M., Kohlbacher, O., Aberger, F., and Huber, C.G. (2020). Proteins and Molecular Pathways Relevant for the Malignant Properties of Tumor-Initiating Pancreatic Cancer Cells. Cells 9.10.3390/cells9061397

  • Schamschula, E., Hagmann, W., Assenov, Y., Hedtfeld, S., Farag, A.K., Roesner, L.M., Wiehlmann, L., Stanke, F., Fischer, S., Risch, A., and Tummler, B. (2020). Immunotyping of clinically divergent p.Phe508del homozygous monozygous cystic fibrosis twins. J Cyst Fibros.10.1016/j.jcf.2020.06.009

  • Scheidt, T., Alka, O., Gonczarowska-Jorge, H., Gruber, W., Rathje, F., Dell'Aica, M., Rurik, M., Kohlbacher, O., Zahedi, R.P., Aberger, F., and Huber, C.G. (2020). Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells. Cell Commun Signal 18, 99.10.1186/s12964-020-00591-0

  • Schlenk, R.F., Paschka, P., Krzykalla, J., Weber, D., Kapp-Schwoerer, S., Gaidzik, V.I., Leis, C., Fiedler, W., Kindler, T., Schroeder, T., Mayer, K., Lubbert, M., Wattad, M., Gotze, K., Horst, H.A., Koller, E., Wulf, G., Schleicher, J., Bentz, M., Greil, R., Hertenstein, B., Krauter, J., Martens, U., Nachbaur, D., Abu Samra, M., Girschikofsky, M., Basara, N., Benner, A., Thol, F., Heuser, M., Ganser, A., Dohner, K., and Dohner, H. (2020). Gemtuzumab Ozogamicin in NPM1-Mutated Acute Myeloid Leukemia: Early Results From the Prospective Randomized AMLSG 09-09 Phase III Study. J Clin Oncol 38, 623-632.10.1200/JCO.19.01406

  • Schneider, C.V., Hamesch, K., Gross, A., Mandorfer, M., Moeller, L.S., Pereira, V., Pons, M., Kuca, P., Reichert, M.C., Benini, F., Burbaum, B., Voss, J., Gutberlet, M., Woditsch, V., Lindhauer, C., Fromme, M., Kumpers, J., Bewersdorf, L., Schafer, B., Eslam, M., Bals, R., Janciauskiene, S., Carvao, J., Neureiter, D., Zhou, B., Woran, K., Bantel, H., Geier, A., Dirrichs, T., Stickel, F., Teumer, A., Verbeek, J., Nevens, F., Govaere, O., Krawczyk, M., Roskams, T., Haybaeck, J., Lurje, G., Chorostowska-Wynimko, J., Genesca, J., Reiberger, T., Zoller, H., Lammert, F., Krag, A., George, J., Anstee, Q.M., Trauner, M., Datz, C., Gaisa, N.T., Denk, H., Trautwein, C., Aigner, E., Strnad, P., and European Alpha-1 Liver Study, G. (2020). Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi *Z Variant of AAT (Pi *MZ vs Pi *ZZ genotype) and Noncarriers. Gastroenterology.10.1053/j.gastro.2020.04.058

  • Singer, C.F., Pfeiler, G., Hubalek, M., Bartsch, R., Stoger, H., Pichler, A., Petru, E., Bjelic-Radisic, V., Greil, R., Rudas, M., Maria Tea, M.K., Wette, V., Petzer, A.L., Sevelda, P., Egle, D., Dubsky, P.C., Filipits, M., Fitzal, F., Exner, R., Jakesz, R., Balic, M., Tinchon, C., Bago-Horvath, Z., Frantal, S., Gnant, M., Austrian, B., and Colorectal Cancer Study, G. (2020). Efficacy and safety of the therapeutic cancer vaccine tecemotide (L-BLP25) in early breast cancer: Results from a prospective, randomised, neoadjuvant phase II study (ABCSG 34). Eur J Cancer 132, 43-52.10.1016/j.ejca.2020.03.018

  • Soh, W.T., Demir, F., Dall, E., Perrar, A., Dahms, S.O., Kuppusamy, M., Brandstetter, H., and Huesgen, P.F. (2020). ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease. Anal Chem 92, 2961-2971.10.1021/acs.analchem.9b03604

  • Tedeschi, A., Greil, R., Demirkan, F., Robak, T., Moreno, C., Barr, P.M., Anz, B., Simpson, D., Gaidano, G., Bairey, O., Stevens, D., Gill, D., Flinn, I.W., Kipps, T.J., Burger, J.A., Lin, J., Webb, T., Fedorov, V., Styles, L., and Gribben, J.G. (2020). A cross-trial comparison of single-agent ibrutinib versus chlorambucil-obinutuzumab in previously untreated patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. Haematologica 105, e164-e168.10.3324/haematol.2019.223743

  • Wagner, S.M., Melchardt, T., Egle, A., Magnes, T., Skrabs, C., Staber, P., Simonitsch-Klupp, I., Panny, M., Lehner, B., Greil, R., Keil, F., Jager, U., and Sillaber, C. (2020a). Treatment with brentuximab vedotin plus bendamustine in unselected patients with CD30-positive aggressive lymphomas. Eur J Haematol 104, 251-258.10.1111/ejh.13368

  • Wagner, S.M., Melchardt, T., and Greil, R. (2020b). Ropeginterferon alfa-2b for the treatment of patients with polycythemia vera. Drugs Today (Barc) 56, 195-202.10.1358/dot.2020.56.3.3107706

  • Wang, Y., Gorlova, O.Y., Gorlov, I.P., Zhu, M., Dai, J., Albanes, D., Lam, S., Tardon, A., Chen, C., Goodman, G.E., Bojesen, S.E., Landi, M.T., Johansson, M., Risch, A., Wichmann, H.E., Bickeboller, H., Christiani, D.C., Rennert, G., Arnold, S.M., Brennan, P., Field, J.K., Shete, S., Le Marchand, L., Melander, O., Brunnstrom, H., Liu, G., Hung, R.J., Andrew, A.S., Kiemeney, L.A., Zienolddiny, S., Grankvist, K., Johansson, M., Caporaso, N.E., Woll, P.J., Lazarus, P., Schabath, M.B., Aldrich, M.C., Stevens, V.L., Ma, H., Jin, G., Hu, Z., Amos, C.I., and Shen, H. (2020). Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls. Cancer Epidemiol Biomarkers Prev 29, 1423-1429.10.1158/1055-9965.EPI-19-1085

  • Wulf, G.G., Altmann, B., Ziepert, M., D'Amore, F., Held, G., Greil, R., Tournilhac, O., Relander, T., Viardot, A., Wilhelm, M., Wilhelm, C., Pezzutto, A., Zijlstra, J.M., Neste, E.V.D., Lugtenburg, P.J., Doorduijn, J.K., Gelder, M.V., van Imhoff, G.W., Zettl, F., Braulke, F., Nickelsen, M., Glass, B., Rosenwald, A., Gaulard, P., Loeffler, M., Pfreundschuh, M., Schmitz, N., Trumper, L., and investigators, A.C.T.s. (2020). Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial. Leukemia.10.1038/s41375-020-0838-5

  • Asslaber, D., Qi, Y., Maeding, N., Steiner, M., Denk, U., Hopner, J.P., Hartmann, T.N., Zaborsky, N., Greil, R., and Egle, A. (2019a). B-cell-specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasion. Blood 134, 1717-1729.10.1182/blood.2019000973

  • Asslaber, D., Wacht, N., Leisch, M., Qi, Y., Maeding, N., Hufnagl, C., Jansko, B., Zaborsky, N., Villunger, A., Hartmann, T.N., Greil, R., and Egle, A. (2019b). BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-kappaB Nuclear Translocation. Clin Cancer Res 25, 1901-1912.10.1158/1078-0432.CCR-18-1548

  • Bolger, G.T., Licollari, A., Bagshaw, R., Tan, A., Greil, R., Vcelar, B., Majeed, M., and Sordillo, P. (2019a). Intense Uptake of Liposomal Curcumin by Multiple Myeloma Cell Lines: Comparison to Normal Lymphocytes, Red Blood Cells and Chronic Lymphocytic Leukemia Cells. Anticancer Res 39, 1161-1168.10.21873/anticanres.13225

  • Bolger, G.T., Licollari, A., Tan, A., Greil, R., Vcelar, B., Greil-Ressler, S., Weiss, L., Schonlieb, C., Magnes, T., Radl, B., Majeed, M., and Sordillo, P.P. (2019b). Pharmacokinetics of liposomal curcumin (Lipocurc) infusion: effect of co-medication in cancer patients and comparison with healthy individuals. Cancer Chemother Pharmacol 83, 265-275.10.1007/s00280-018-3730-5

  • Burtness, B., Harrington, K.J., Greil, R., Soulieres, D., Tahara, M., de Castro, G., Jr., Psyrri, A., Baste, N., Neupane, P., Bratland, A., Fuereder, T., Hughes, B.G.M., Mesia, R., Ngamphaiboon, N., Rordorf, T., Wan Ishak, W.Z., Hong, R.L., Gonzalez Mendoza, R., Roy, A., Zhang, Y., Gumuscu, B., Cheng, J.D., Jin, F., Rischin, D., and Investigators, K.-. (2019). Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet 394, 1915-1928.10.1016/S0140-6736(19)32591-7

  • Egle, A., Melchardt, T., Obrtlikova, P., Smolej, L., Kozak, T., Steurer, M., Andel, J., Burgstaller, S., Mikuskova, E., Gercheva, L., Nosslinger, T., Papajik, T., Ladicka, M., Girschikofsky, M., Hrubisko, M., Jager, U., Voskova, D., Pecherstorfer, M., Kralikova, E., Burcoveanu, C., Spasov, E., Petzer, A., Mihaylov, G., Raynov, J., Oexle, H., Zabernigg, A., Flochova, E., Palasthy, S., Stehlikova, O., Doubek, M., Altenhofer, P., Weiss, L., Magnes, T., Pleyer, L., Klingler, A., Mayer, J., and Greil, R. (2019). Rituximab maintenance overcomes the negative prognostic factor of obesity in CLL: Subgroup analysis of the international randomized AGMT CLL-8a mabtenance trial. Cancer Med 8, 1401-1405.10.1002/cam4.1980

  • Filipits, M., Dubsky, P., Rudas, M., Greil, R., Balic, M., Bago-Horvath, Z., Singer, C.F., Hlauschek, D., Brown, K., Bernhisel, R., Kronenwett, R., Lancaster, J.M., Fitzal, F., and Gnant, M. (2019). Prediction of Distant Recurrence Using EndoPredict Among Women with ER(+), HER2(-) Node-Positive and Node-Negative Breast Cancer Treated with Endocrine Therapy Only. Clin Cancer Res 25, 3865-3872.10.1158/1078-0432.CCR-19-0376

  • Gampenrieder, S.P., Peer, A., Weismann, C., Meissnitzer, M., Rinnerthaler, G., Webhofer, J., Westphal, T., Riedmann, M., Meissnitzer, T., Egger, H., Klaassen Federspiel, F., Reitsamer, R., Hauser-Kronberger, C., Stering, K., Hergan, K., Mlineritsch, B., and Greil, R. (2019). Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR). Breast Cancer Res 21, 19.10.1186/s13058-018-1091-y

  • Gnant, M., Pfeiler, G., Steger, G.G., Egle, D., Greil, R., Fitzal, F., Wette, V., Balic, M., Haslbauer, F., Melbinger-Zeinitzer, E., Bjelic-Radisic, V., Jakesz, R., Marth, C., Sevelda, P., Mlineritsch, B., Exner, R., Fesl, C., Frantal, S., Singer, C.F., Austrian, B., and Colorectal Cancer Study, G. (2019). Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol 20, 339-351.10.1016/S1470-2045(18)30862-3

  • Huemer, F., Melchardt, T., Jansko, B., Wahida, A., Jilg, S., Jost, P.J., Klieser, E., Steiger, K., Magnes, T., Pleyer, L., Greil-Ressler, S., Rass, C., Greil, R., and Egle, A. (2019a). Durable remissions with venetoclax monotherapy in secondary AML refractory to hypomethylating agents and high expression of BCL-2 and/or BIM. Eur J Haematol 102, 437-441.10.1111/ejh.13218

  • Huemer, F., Rinnerthaler, G., Lang, D., Hackl, H., Lamprecht, B., and Greil, R. (2019b). Association between antibiotics use and outcome in patients with NSCLC treated with immunotherapeutics. Ann Oncol 30, 652-653.10.1093/annonc/mdz021

  • Lang, D., Huemer, F., Rinnerthaler, G., Horner, A., Wass, R., Brehm, E., Akbari, K., Granitz, M., Hutarew, G., Kaiser, B., Greil, R., and Lamprecht, B. (2019). Therapy Line and Associated Predictors of Response to PD-1/PD-L1-Inhibitor Monotherapy in Advanced Non-small-Cell Lung Cancer: A Retrospective Bi-centric Cohort Study. Target Oncol 14, 707-717.10.1007/s11523-019-00679-9

  • Leisch, M., Egle, A., and Greil, R. (2019a). Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma. Future Oncol 15, 109-120.10.2217/fon-2018-0492

  • Leisch, M., Jansko, B., Zaborsky, N., Greil, R., and Pleyer, L. (2019b). Next Generation Sequencing in AML-On the Way to Becoming a New Standard for Treatment Initiation and/or Modulation? Cancers (Basel) 11.10.3390/cancers11020252

  • Ludwig, H., Poenisch, W., Knop, S., Egle, A., Schreder, M., Lechner, D., Hajek, R., Gunsilius, E., Krenosz, K.J., Petzer, A., Weisel, K., Niederwieser, D., Einsele, H., Willenbacher, W., Melchardt, T., Greil, R., and Zojer, N. (2019). Ixazomib-Thalidomide-Dexamethasone for induction therapy followed by Ixazomib maintenance treatment in patients with relapsed/refractory multiple myeloma. Br J Cancer 121, 751-757.10.1038/s41416-019-0581-8

  • Matikas, A., Foukakis, T., Moebus, V., Greil, R., Bengtsson, N.O., Steger, G.G., Untch, M., Johansson, H., Hellstrom, M., Malmstrom, P., Gnant, M., Loibl, S., and Bergh, J. (2019). Dose tailoring of adjuvant chemotherapy for breast cancer based on hematologic toxicities: further results from the prospective PANTHER study with focus on obese patients. Ann Oncol 30, 109-114.10.1093/annonc/mdy475

  • Moreno, C., Greil, R., Demirkan, F., Tedeschi, A., Anz, B., Larratt, L., Simkovic, M., Samoilova, O., Novak, J., Ben-Yehuda, D., Strugov, V., Gill, D., Gribben, J.G., Hsu, E., Lih, C.J., Zhou, C., Clow, F., James, D.F., Styles, L., and Flinn, I.W. (2019). Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 20, 43-56.10.1016/S1470-2045(18)30788-5

  • Parigger, T., Greil, R., and Zaborsky, N. (2019). Mouse models to decipher anti-tumor immunity. Oncotarget 10, 5005-5006.10.18632/oncotarget.27111

  • Rinnerthaler, G., Gampenrieder, S.P., and Greil, R. (2019). HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer. Int J Mol Sci 20.10.3390/ijms20051115

  • Scheithauer, W., Putora, P.M., Grunberger, B., Eisterer, W., Woll, E., Prager, G., Schaberl-Moser, R., Greil, R., and Glatzer, M. (2019). Patterns of care in metastatic pancreatic cancer: patient selection in clinical routine. Therap Adv Gastroenterol 12, 1756284819877635.10.1177/1756284819877635

  • Schlenk, R.F., Weber, D., Fiedler, W., Salih, H.R., Wulf, G., Salwender, H., Schroeder, T., Kindler, T., Lubbert, M., Wolf, D., Westermann, J., Kraemer, D., Gotze, K.S., Horst, H.A., Krauter, J., Girschikofsky, M., Ringhoffer, M., Sudhoff, T., Held, G., Derigs, H.G., Schroers, R., Greil, R., Griesshammer, M., Lange, E., Burchardt, A., Martens, U., Hertenstein, B., Marretta, L., Heuser, M., Thol, F., Gaidzik, V.I., Herr, W., Krzykalla, J., Benner, A., Dohner, K., Ganser, A., Paschka, P., Dohner, H., and German-Austrian, A.M.L.S.G. (2019). Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD. Blood 133, 840-851.10.1182/blood-2018-08-869453

  • Spicka, I., Ocio, E.M., Oakervee, H.E., Greil, R., Banh, R.H., Huang, S.Y., D'Rozario, J.M., Dimopoulos, M.A., Martinez, S., Extremera, S., Kahatt, C., Alfaro, V., Carella, A.M., Meuleman, N., Hajek, R., Symeonidis, A., Min, C.K., Cannell, P., Ludwig, H., Sonneveld, P., and Mateos, M.V. (2019). Randomized phase III study (ADMYRE) of plitidepsin in combination with dexamethasone vs. dexamethasone alone in patients with relapsed/refractory multiple myeloma. Ann Hematol 98, 2139-2150.10.1007/s00277-019-03739-2

  • Willer, J., Johrer, K., Greil, R., Zidorn, C., and Cicek, S.S. (2019). Cytotoxic Properties of Damiana (Turnera diffusa) Extracts and Constituents and A Validated Quantitative UHPLC-DAD Assay. Molecules 24.10.3390/molecules24050855

  • Zaborsky, N., Gassner, F.J., Hopner, J.P., Schubert, M., Hebenstreit, D., Stark, R., Asslaber, D., Steiner, M., Geisberger, R., Greil, R., and Egle, A. (2019). Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development. Leukemia 33, 957-968.10.1038/s41375-018-0260-4

Translational cancer research at CCS

Bench-to-bedside and bedside-to-bench work

The scientific strategy and conceptual organization of CCS allows both the validation of basic research findings in clinical settings (bench to bedside) and the detailed molecular analysis of clinical observations in predictive in vitro and in vivo model systems (bedside to bench). This bidirectional research strategy accelerates the discovery of novel and innovative therapeutic approaches for personalized cancer therapy. 

Funding & Support

Cancer Cluster Salzburg at SCRI

3rd Medical Department

Paracelsus Medical University Clinics Salzburg

Müllner Hauptstrasse 48, 5020 Salzburg, Austria

Email: ccs@sbg.ac.at

Cancer Cluster Salzburg at PLUS

Department of Biosciences

University of Salzburg

Hellbrunner Strasse 34, 5020 Salzburg, Austria

Email: ccs@sbg.ac.at