Epigenetic and embryonic pathways in solid and lymphatic tumors
The experimental and translational investigation of epigenetic regulatory mechanism like DNA-methylation, Histone-acetylation and miRNA profiling (i) in solid tumors of the gastro-intestinal-tract, especially of the hepato-biliary-pancreatic system, (ii) as well as in hematologic malignancies (MDS, MALT-lymphoma, diffuse large B-cell lymphoma) are the recent scientific focuses of the research group of Neureiter, Illig and Klieser at the Institute of Pathology (SALK/PMU).
In the last year, it was shown that epigenetic deregulations are key events in human cancerogenesis; additionally, linkages between epigenetic alterations and tumor pathways (such as β-Catenin-WNT or Hedgehog pathway) were established. Moreover, national and international co-operations exist to solve these complex scientific questions resulting in many publications in peer-review journals. The final aim of these investigations is to select that promising tumor sub-entity with the best therapeutic effect by targeted therapy in future.
Daniel Neureiter, MD
Institute of Pathology
University Clinics Salzburg
Paracelus Medical Private University
Epigenetic and developmental pathways in cancer
Within CCS we focus on investigations of signal cascades in a variety of tumor entities applying different molecular techniques (such as western blot, immunhistochemistry, tissue micro arrays as well as cell-cycle-analysis) in-vitro and in-vivo as well as in-situ to characterize specific cellular and molecular pathways of differentiation, proliferation and apoptosis.