CCS researchers identify cross-talk between Hedgehog/GLI and PI3K signaling with therapeutic relevan
In a joint study, the CCS groups Aberger, Hartmann and Greil addressed the role of Hedgehog (HH)/GLI and its putative interaction with the PI3K/AKT cascade in the initiation and maintenance of chronic lymphocytic leukemia (CLL). Using transgenic mouse models, they show that HH/GLI signaling alone or in combination with PI3K/AKT does not suffice to initiate a CLL-like phenotype. By contrast, the work identifies a critical role of GLI and PI3K signaling for the survival of human primary CLL cells, and further shows that combined targeting of GLI and PI3K/AKT/mTOR signaling has a synergistic therapeutic effect. The data provide a basis for rational combination therapies targeting HH/GLI and PI3K signaling in this common hematopoietic malignancy. The study by Kern et al. has been published as open access article in Oncogene. > read the paper.