• CCS Authors Team

CCS researchers identify cross-talk between Hedgehog/GLI and PI3K signaling with therapeutic relevan

In a joint study, the CCS groups Aberger, Hartmann and Greil addressed the role of Hedgehog (HH)/GLI and its putative interaction with the PI3K/AKT cascade in the initiation and maintenance of chronic lymphocytic leukemia (CLL). Using transgenic mouse models, they show that HH/GLI signaling alone or in combination with PI3K/AKT does not suffice to initiate a CLL-like phenotype. By contrast, the work identifies a critical role of GLI and PI3K signaling for the survival of human primary CLL cells, and further shows that combined targeting of GLI and PI3K/AKT/mTOR signaling has a synergistic therapeutic effect. The data provide a basis for rational combination therapies targeting HH/GLI and PI3K signaling in this common hematopoietic malignancy. The study by Kern et al. has been published as open access article in Oncogene. > read the paper.


Cancer Cluster Salzburg at SCRI

3rd Medical Department

Paracelsus Medical University Clinics Salzburg

Müllner Hauptstrasse 48, 5020 Salzburg, Austria


Cancer Cluster Salzburg at PLUS

Department of Biosciences

University of Salzburg

Hellbrunner Strasse 34, 5020 Salzburg, Austria