• CCS Authors Team

New insights into the role of Kallikrein proteases in cancer

Kallikrein-related peptidase 2 (KLK2) is a key serine protease involved in the metastatic progression of prostate cancer. The Brandstetter lab now identified that post-translation modification of KLK2 by glycosylation regulates its activation and enzymatic activity. These striking effects of glycosylation pave the way to a deeper understanding of kallikrein-related peptidase function in malignant progression. The study by Shihui Guo et al. has been published in the Journal of Biological Chemistry and can be found here.


Cancer Cluster Salzburg at SCRI

3rd Medical Department

Paracelsus Medical University Clinics Salzburg

Müllner Hauptstrasse 48, 5020 Salzburg, Austria


Cancer Cluster Salzburg at PLUS

Department of Biosciences

University of Salzburg

Hellbrunner Strasse 34, 5020 Salzburg, Austria