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New insights into the role of Kallikrein proteases in cancer


Kallikrein-related peptidase 2 (KLK2) is a key serine protease involved in the metastatic progression of prostate cancer. The Brandstetter lab now identified that post-translation modification of KLK2 by glycosylation regulates its activation and enzymatic activity. These striking effects of glycosylation pave the way to a deeper understanding of kallikrein-related peptidase function in malignant progression. The study by Shihui Guo et al. has been published in the Journal of Biological Chemistry and can be found here.


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Cancer Cluster Salzburg at SCRI

3rd Medical Department

Paracelsus Medical University Clinics Salzburg

Müllner Hauptstrasse 48, 5020 Salzburg, Austria

Email: ccs@sbg.ac.at

Cancer Cluster Salzburg at PLUS

Department of Biosciences

University of Salzburg

Hellbrunner Strasse 34, 5020 Salzburg, Austria

Email: ccs@sbg.ac.at