CCS Research
CCS Publications
  • Zhou F, Wang Y, Liu H, Ready N, Han Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeboller H, Rosenberger A, Houlston RS, et al. Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. Molecular carcinogenesis 2017;56: 1227-38.

  • Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nature communications 2017;8: 14740.

  • Yin J, Liu H, Liu Z, Owzar K, Han Y, Su L, Wei Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeboeller H, et al. Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus. Molecular carcinogenesis 2017;56: 1663-72.

  • Woll E, Thaler J, Keil F, Gruenberger B, Hejna M, Eisterer W, Fridrik MA, Ulmer H, Trommet V, Huemer F, Weiss L, Greil R. Oxaliplatin/Irinotecan/Bevacizumab Followed by Docetaxel/Bevacizumab in Inoperable Locally Advanced or Metastatic Gastric Cancer Patients - AGMT_GASTRIC-3. Anticancer research 2017;37: 5553-8.

  • Wolff F, Leisch M, Greil R, Risch A, Pleyer L. The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation. Cell communication and signaling : CCS 2017;15: 13.

  • Wessler S, Schneider G, Backert S. Bacterial serine protease HtrA as a promising new target for antimicrobial therapy? Cell communication and signaling : CCS 2017;15: 4.

  • Wessler S, Krisch LM, Elmer DP, Aberger F. From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases. Cell communication and signaling : CCS 2017;15: 15.

  • Wessler S, Backert S. A novel basolateral type IV secretion model for the CagA oncoprotein of Helicobacter pylori. Microb Cell 2017;5: 60-2.

  • Wessler S, Aberger F, Hartmann TN. The sound of tumor cell-microenvironment communication - composed by the Cancer Cluster Salzburg research network. Cell communication and signaling : CCS 2017;15: 20.

  • Weiss L, Melchardt T, Egle A, Hopfinger G, Hackl H, Greil R, Barth J, Rummel M. Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial. Annals of hematology 2017;96: 1155-62.

  • Weiss L, Huemer F, Greil R. ASCO-update: gastrointestinal tumors. Memo 2017;10: 240-3.

  • Wang Y, McKay JD, Rafnar T, Wang Z, Timofeeva MN, Broderick P, Zong X, Laplana M, Wei Y, Han Y, Lloyd A, Delahaye-Sourdeix M, et al. Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nature genetics 2017;49: 651.

  • Toth R, Scherer D, Kelemen LE, Risch A, Hazra A, Balavarca Y, Issa JJ, Moreno V, Eeles RA, Ogino S, Wu X, Ye Y, et al. Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017;26: 816-25.

  • Thieblemont C, Tilly H, Gomes da Silva M, Casasnovas RO, Fruchart C, Morschhauser F, Haioun C, Lazarovici J, Grosicka A, Perrot A, Trotman J, Sebban C, et al. Lenalidomide Maintenance Compared With Placebo in Responding Elderly Patients With Diffuse Large B-Cell Lymphoma Treated With First-Line Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017;35: 2473-81.

  • Tegtmeyer N, Wessler S, Necchi V, Rohde M, Harrer A, Rau TT, Asche CI, Boehm M, Loessner H, Figueiredo C, Naumann M, Palmisano R, et al. Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery. Cell host & microbe 2017;22: 552-60 e5.

  • Taylor N, Kremser I, Auer S, Hoermann G, Greil R, Haschke-Becher E, Esterbauer H, Kenner L, Oberkofler H. Hemeoxygenase-1 as a Novel Driver in Ritonavir-Induced Insulin Resistance in HIV-1-Infected Patients. J Acquir Immune Defic Syndr 2017;75: e13-e20.

  • Tanwar S, Trembling PM, Hogan BJ, Srivastava A, Parkes J, Harris S, Grant P, Nastouli E, Ocker M, Wehr K, Herold C, Neureiter D, et al. Noninvasive markers of liver fibrosis: on-treatment changes of serum markers predict the outcome of antifibrotic therapy. Eur J Gastroenterol Hepatol 2017;29: 289-96.

  • Tanwar S, Trembling PM, Hogan BJ, Parkes J, Harris S, Grant P, Nastouli E, Ocker M, Wehr K, Herold C, Neureiter D, Schuppan D, et al. Biomarkers of Hepatic Fibrosis in Chronic Hepatitis C: A Comparison of 10 Biomarkers Using 2 Different Assays for Hyaluronic Acid. J Clin Gastroenterol 2017;51: 268-77.

  • Suhr M, Risch AK, Wilz G. Maintaining Mental Health Through Positive Writing: Effects of a Resource Diary on Depression and Emotion Regulation. J Clin Psychol 2017;73: 1586-98.

  • Stutz K, Muller AT, Hiss JA, Schneider P, Blatter M, Pfeiffer B, Posselt G, Kanfer G, Kornmann B, Wrede P, Altmann KH, Wessler S, et al. Peptide-Membrane Interaction between Targeting and Lysis. ACS chemical biology 2017;12: 2254-9.

  • Strandt H, Pinheiro DF, Kaplan DH, Wirth D, Gratz IK, Hammerl P, Thalhamer J, Stoecklinger A. Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance. J Immunol 2017;199: 1626-34.

  • Schwarz H, Gornicec J, Neuper T, Parigiani MA, Wallner M, Duschl A, Horejs-Hoeck J. Biological Activity of Masked Endotoxin. Sci Rep 2017;7: 44750.

  • Schwaiger K, Ensat F, Neureiter D, Wechselberger G, Hladik M. Trigger Finger Caused by Extraskeletal Chondroma. J Hand Surg Am 2017;42: e51-e5.

  • Schuh AC, Dohner H, Pleyer L, Seymour JF, Fenaux P, Dombret H. Azacitidine in adult patients with acute myeloid leukemia. Crit Rev Oncol Hematol 2017;116: 159-77.

  • Schneider P, Muller AT, Gabernet G, Button AL, Posselt G, Wessler S, Hiss JA, Schneider G. Hybrid Network Model for "Deep Learning" of Chemical Data: Application to Antimicrobial Peptides. Mol Inform 2017;36.

  • Ruggenthaler M, Grass J, Schuh W, Huber CG, Reischl RJ. Levothyroxine sodium revisited: A wholistic structural elucidation approach of new impurities via HPLC-HRMS/MS, on-line H/D exchange, NMR spectroscopy and chemical synthesis. J Pharm Biomed Anal 2017;135: 140-52.

  • Ruggenthaler M, Grass J, Schuh W, Huber CG, Reischl RJ. Impurity profiling of liothyronine sodium by means of reversed phase HPLC, high resolution mass spectrometry, on-line H/D exchange and UV/Vis absorption. J Pharm Biomed Anal 2017;143: 147-58.

  • Rosenberger A, Sohns M, Friedrichs S, Hung RJ, Fehringer G, McLaughlin J, Amos CI, Brennan P, Risch A, Bruske I, Caporaso NE, Landi MT, et al. Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus. PloS one 2017;12: e0173339.

  • Roschger C, Neukirchen S, Elsasser B, Schubert M, Maeding N, Verwanger T, Krammer B, Cabrele C. Targeting of a Helix-Loop-Helix Transcriptional Regulator by a Short Helical Peptide. ChemMedChem 2017;12: 1497-503.

  • Roschger C, Cabrele C. The Id-protein family in developmental and cancer-associated pathways. Cell communication and signaling : CCS 2017;15: 7.

  • Riedl D, Giesinger JM, Wintner LM, Loth FL, Rumpold G, Greil R, Nickels A, Licht T, Holzner B. Improvement of quality of life and psychological distress after inpatient cancer rehabilitation : Results of a longitudinal observational study. Wiener klinische Wochenschrift 2017;129: 692-701.

  • Regl C, Wohlschlager T, Holzmann J, Huber CG. A Generic HPLC Method for Absolute Quantification of Oxidation in Monoclonal Antibodies and Fc-Fusion Proteins Using UV and MS Detection. Anal Chem 2017;89: 8391-8.

  • Posselt G, Crabtree JE, Wessler S. Proteolysis in Helicobacter pylori-Induced Gastric Cancer. Toxins (Basel) 2017;9.

  • Pleyer L, Dohner H, Dombret H, Seymour JF, Schuh AC, Beach CL, Swern AS, Burgstaller S, Stauder R, Girschikofsky M, Sill H, Schlick K, et al. Azacitidine for Front-Line Therapy of Patients with AML: Reproducible Efficacy Established by Direct Comparison of International Phase 3 Trial Data with Registry Data from the Austrian Azacitidine Registry of the AGMT Study Group. International journal of molecular sciences 2017;18.

  • Pillong M, Hiss JA, Schneider P, Lin YC, Posselt G, Pfeiffer B, Blatter M, Muller AT, Bachler S, Neuhaus CS, Dittrich PS, Altmann KH, et al. Rational Design of Membrane-Pore-Forming Peptides. Small 2017;13.

  • Pan Y, Liu H, Wang Y, Kang X, Liu Z, Owzar K, Han Y, Su L, Wei Y, Hung RJ, Brhane Y, McLaughlin J, et al. Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep 2017;7: 44634.

  • Padberg S, Mick I, Frenzel C, Greil R, Hilberath J, Schaefer C. Transient congenital dilated cardiomyopathy after maternal R-CHOP chemotherapy during pregnancy. Reprod Toxicol 2017;71: 146-9.

  • Neuper T, Ellwanger K, Schwarz H, Kufer TA, Duschl A, Horejs-Hoeck J. NOD1 modulates IL-10 signalling in human dendritic cells. Sci Rep 2017;7: 1005.

  • Neukirchen S, Krieger V, Roschger C, Schubert M, Elsasser B, Cabrele C. Impact of the amino acid sequence on the conformation of side chain lactam-bridged octapeptides. Journal of peptide science : an official publication of the European Peptide Society 2017;23: 587-96.

  • McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, et al. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nature genetics 2017;49: 1126-32.

  • Mayr C, Ocker M, Ritter M, Pichler M, Neureiter D, Kiesslich T. Biliary tract cancer stem cells - translational options and challenges. World journal of gastroenterology : WJG 2017;23: 2470-82.

  • Magnes T, Melchardt T, Weiss L, Mittermair C, Neureiter D, Klieser E, Gampenrieder S, Moser G, Gaggl A, Greil R, Egle A. Prognostic score in patients with recurrent or metastatic carcinoma of the head and neck treated with cetuximab and chemotherapy. PloS one 2017;12: e0180995.

  • Magnes T, Melchardt T, Hufnagl C, Weiss L, Mittermair C, Neureiter D, Klieser E, Rinnerthaler G, Roesch S, Gaggl A, Greil R, Egle A. The influence of FCGR2A and FCGR3A polymorphisms on the survival of patients with recurrent or metastatic squamous cell head and neck cancer treated with cetuximab. Pharmacogenomics J 2018;18: 474-9.

  • Magnes T, Egle A, Greil R, Melchardt T. Update on squamous cell carcinoma of the head and neck: ASCO annual meeting 2017. Memo 2017;10: 220-3.

  • Ludwig H, Weisel K, Petrucci MT, Leleu X, Cafro AM, Garderet L, Leitgeb C, Foa R, Greil R, Yakoub-Agha I, Zboralski D, Vauleon S, et al. Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib-dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study. Leukemia 2017;31: 997-1000.

  • Lu L, Chen J, Robb SMC, Okumoto Y, Stajich JE, Wessler SR. Tracking the genome-wide outcomes of a transposable element burst over decades of amplification. Proceedings of the National Academy of Sciences of the United States of America 2017;114: E10550-E9.

  • Liu K, Wessler SR. Functional characterization of the active Mutator-like transposable element, Muta1 from the mosquito Aedes aegypti. Mob DNA 2017;8: 1.

  • Liu K, Wessler SR. Transposition of Mutator-like transposable elements (MULEs) resembles hAT and Transib elements and V(D)J recombination. Nucleic Acids Res 2017;45: 6644-55.

  • Liu H, Liu Z, Wang Y, Stinchcombe TE, Owzar K, Han Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeboller H, Rosenberger A, et al. Functional variants in DCAF4 associated with lung cancer risk in European populations. Carcinogenesis 2017;38: 541-51.

  • Li Y, Shi Z, Radauer-Preiml I, Andosch A, Casals E, Luetz-Meindl U, Cobaleda M, Lin Z, Jaberi-Douraki M, Italiani P, Horejs-Hoeck J, Himly M, et al. Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation. Nanotoxicology 2017;11: 1157-75.

  • Leisch M, Weiss L, Lindlbauer N, Jungbauer C, Egle A, Rohde E, Greil R, Grabmer C, Pleyer L. Red blood cell alloimmunization in 184 patients with myeloid neoplasms treated with azacitidine - A retrospective single center experience. Leukemia research 2017;59: 12-9.

  • Lee M, Neukirchen S, Cabrele C, Reiser O. Visible-light photoredox-catalyzed desulfurization of thiol- and disulfide-containing amino acids and small peptides. Journal of peptide science : an official publication of the European Peptide Society 2017;23: 556-62.

  • Klieser E, Urbas R, Stattner S, Primavesi F, Jager T, Dinnewitzer A, Mayr C, Kiesslich T, Holzmann K, Di Fazio P, Neureiter D, Swierczynski S. Comprehensive immunohistochemical analysis of histone deacetylases in pancreatic neuroendocrine tumors: HDAC5 as a predictor of poor clinical outcome. Human pathology 2017;65: 41-52.

  • Kiesewetter B, Willenbacher E, Willenbacher W, Egle A, Neumeister P, Voskova D, Mayerhoefer ME, Simonitsch-Klupp I, Melchardt T, Greil R, Raderer M, Investigators A. A phase 2 study of rituximab plus lenalidomide for mucosa-associated lymphoid tissue lymphoma. Blood 2017;129: 383-5.

  • Kazianka L, Drucker C, Skrabs C, Thomas W, Melchardt T, Struve S, Bergmann M, Staber PB, Porpaczy E, Einberger C, Heinz M, Hauswirth A, et al. Ristocetin-induced platelet aggregation for monitoring of bleeding tendency in CLL treated with ibrutinib. Leukemia 2017;31: 1117-22.

  • Jager T, Ocker M, Kiesslich T, Neureiter E, Neureiter D. Thoughts on investigational hedgehog pathway inhibitors for the treatment of cancer. Expert Opin Investig Drugs 2017;26: 133-6.

  • Jager T, Neureiter D, Urbas R, Klieser E, Hitzl W, Emmanuel K, Dinnewitzer A. Applicability of American Joint Committee on Cancer and College of American Pathologists Regression Grading System in Rectal Cancer. Diseases of the colon and rectum 2017;60: 815-26.

  • Huemer F, Dejaco M, Grabmer C, Melchardt T, Neureiter D, Mayer G, Egle A, Greil R, Weiss L. Intermittent low-dose bevacizumab in hereditary hemorrhagic telangiectasia : A case report. Wiener klinische Wochenschrift 2017;129: 141-4.

  • Gu F, Zhang H, Hyland PL, Berndt S, Gapstur SM, Wheeler W, Ellipse Consortium T, Amos CI, Bezieau S, Bickeboller H, Brenner H, Brennan P, et al. Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia. International journal of cancer Journal international du cancer 2017;141: 1794-802.

  • Gruber W, Scheidt T, Aberger F, Huber CG. Understanding cell signaling in cancer stem cells for targeted therapy - can phosphoproteomics help to reveal the secrets? Cell communication and signaling : CCS 2017;15: 12.

  • Groh A, Rhein M, Buchholz V, Burkert A, Huber CG, Lang UE, Borgwardt SJ, Heberlein A, Muschler MAN, Hillemacher T, Bleich S, Frieling H, et al. Epigenetic Effects of Intravenous Diacetylmorphine on the Methylation of POMC and NR3C1. Neuropsychobiology 2017;75: 193-9.

  • Greil R, Hutterer E, Hartmann TN, Pleyer L. Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation. Cell communication and signaling : CCS 2017;15: 5.

  • Grassi L, Regl C, Wildner S, Gadermaier G, Huber CG, Cabrele C, Schubert M. Complete NMR Assignment of Succinimide and Its Detection and Quantification in Peptides and Intact Proteins. Anal Chem 2017;89: 11962-70.

  • Gampenrieder SP, Westphal T, Greil R. Antiangiogenic therapy in breast cancer. Memo 2017;10: 194-201.

  • Gampenrieder SP, Rinnerthaler G, Greil R. SABCS 2016: systemic therapy for metastatic breast cancer. Memo 2017;10: 86-9.

  • Gampenrieder SP, Hufnagl C, Brechelmacher S, Huemer F, Hackl H, Rinnerthaler G, Romeder F, Monzo Fuentes C, Morre P, Hauser-Kronberger C, Mlineritsch B, Greil R. Endothelin-1 genetic polymorphism as predictive marker for bevacizumab in metastatic breast cancer. Pharmacogenomics J 2017;17: 344-50.

  • Friedrichs S, Manitz J, Burger P, Amos CI, Risch A, Chang-Claude J, Wichmann HE, Kneib T, Bickeboller H, Hofner B. Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies. Comput Math Methods Med 2017;2017: 6742763.

  • Feng Y, Wang Y, Liu H, Liu Z, Mills C, Han Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeboeller H, Rosenberger A, et al. Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium. Sci Rep 2017;7: 825.

  • Feichtinger RG, Neureiter D, Skaria T, Wessler S, Cover TL, Mayr JA, Zimmermann FA, Posselt G, Sperl W, Kofler B. Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis. Oxid Med Cell Longev 2017;2017: 1320241.

  • Elsasser B, Zauner FB, Messner J, Soh WT, Dall E, Brandstetter H. Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations. ACS Catal 2017;7: 5585-93.

  • Eisterer W, Piringer G, A DEV, Ofner D, Greil R, Tschmelitsch J, Samonigg H, Solkner L, Gnant M, Thaler J, Austrian B, Colorectal Cancer Study G. Neoadjuvant Chemotherapy with Capecitabine, Oxaliplatin and Bevacizumab Followed by Concomitant Chemoradiation and Surgical Resection in Locally Advanced Rectal Cancer with High Risk of Recurrence - A Phase II Study. Anticancer research 2017;37: 2683-91.

  • Egle A. Milestones in Chronic Lymphocytic Leukemia: An exciting decade of progress-10th anniversary of memo. Memo 2017;10: 8-12.

  • Dukorn S, Littmann T, Keller M, Kuhn K, Cabrele C, Baumeister P, Bernhardt G, Buschauer A. Fluorescence- and Radiolabeling of [Lys(4),Nle(17,30)]hPP Yields Molecular Tools for the NPY Y4 Receptor. Bioconjug Chem 2017;28: 1291-304.

  • Catakovic K, Klieser E, Neureiter D, Geisberger R. T cell exhaustion: from pathophysiological basics to tumor immunotherapy. Cell communication and signaling : CCS 2017;15: 1.

  • Catakovic K, Gassner FJ, Ratswohl C, Zaborsky N, Rebhandl S, Schubert M, Steiner M, Gutjahr JC, Pleyer L, Egle A, Hartmann TN, Greil R, et al. TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia. Oncoimmunology 2017;7: e1371399.

  • Carreras-Torres R, Johansson M, Haycock PC, Wade KH, Relton CL, Martin RM, Davey Smith G, Albanes D, Aldrich MC, Andrew A, Arnold SM, Bickeboller H, et al. Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study. PloS one 2017;12: e0177875.

  • Braga SF, Martins LC, da Silva EB, Sales Junior PA, Murta SM, Romanha AJ, Soh WT, Brandstetter H, Ferreira RS, de Oliveira RB. Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification. Bioorg Med Chem 2017;25: 1889-900.

  • Borchmann P, Haverkamp H, Lohri A, Mey U, Kreissl S, Greil R, Markova J, Feuring-Buske M, Meissner J, Duhrsen U, Ostermann H, Keller U, et al. Progression-free survival of early interim PET-positive patients with advanced stage Hodgkin's lymphoma treated with BEACOPPescalated alone or in combination with rituximab (HD18): an open-label, international, randomised phase 3 study by the German Hodgkin Study Group. The Lancet Oncology 2017;18: 454-63.

  • Bolger GT, Licollari A, Tan A, Greil R, Vcelar B, Majeed M, Helson L. Distribution and Metabolism of Lipocurc (Liposomal Curcumin) in Dog and Human Blood Cells: Species Selectivity and Pharmacokinetic Relevance. Anticancer research 2017;37: 3483-92.

  • Benz K, Varga I, Neureiter D, Campean V, Daniel C, Heim C, Reimann A, Weyand M, Hilgers KF, Amann K. Vascular inflammation and media calcification are already present in early stages of chronic kidney disease. Cardiovasc Pathol 2017;27: 57-67.

  • Bauer JW, Koller J, Murauer EM, De Rosa L, Enzo E, Carulli S, Bondanza S, Recchia A, Muss W, Diem A, Mayr E, Schlager P, et al. Closure of a Large Chronic Wound through Transplantation of Gene-Corrected Epidermal Stem Cells. J Invest Dermatol 2017;137: 778-81.

  • Baglietto L, Ponzi E, Haycock P, Hodge A, Bianca Assumma M, Jung CH, Chung J, Fasanelli F, Guida F, Campanella G, Chadeau-Hyam M, Grankvist K, et al. DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk. International journal of cancer Journal international du cancer 2017;140: 50-61.

  • Backert S, Schmidt TP, Harrer A, Wessler S. Exploiting the Gastric Epithelial Barrier: Helicobacter pylori's Attack on Tight and Adherens Junctions. Curr Top Microbiol Immunol 2017;400: 195-226.

  • Auer S, Rinnerthaler M, Bischof J, Streubel MK, Breitenbach-Koller H, Geisberger R, Aigner E, Cadamuro J, Richter K, Sopjani M, Haschke-Becher E, Felder TK, et al. The Human NADPH Oxidase, Nox4, Regulates Cytoskeletal Organization in Two Cancer Cell Lines, HepG2 and SH-SY5Y. Front Oncol 2017;7: 111.

  • Amos CI, Dennis J, Wang Z, Byun J, Schumacher FR, Gayther SA, Casey G, Hunter DJ, Sellers TA, Gruber SB, Dunning AM, Michailidou K, et al. The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017;26: 126-35.

  • Almeida AM, Prebet T, Itzykson R, Ramos F, Al-Ali H, Shammo J, Pinto R, Maurillo L, Wetzel J, Musto P, Van De Loosdrecht AA, Costa MJ, et al. Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study. International journal of molecular sciences 2017;18.

  • Aberger F, Hutterer E, Sternberg C, Del Burgo PJ, Hartmann TN. Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling. Cell communication and signaling : CCS 2017;15: 8.

Translational cancer research at CCS

Bench-to-bedside and bedside-to-bench work

The scientific strategy and conceptual organization of CCS allows both the validation of basic research findings in clinical settings (bench to bedside) and the detailed molecular analysis of clinical observations in predictive in vitro and in vivo model systems (bedside to bench). This bidirectional research strategy accelerates the discovery of novel and innovative therapeutic approaches for personalized cancer therapy. 

Funding & Support

Cancer Cluster Salzburg at SCRI

3rd Medical Department

Paracelsus Medical University Clinics Salzburg

Müllner Hauptstrasse 48, 5020 Salzburg, Austria


Cancer Cluster Salzburg at PLUS

Department of Biosciences

University of Salzburg

Hellbrunner Strasse 34, 5020 Salzburg, Austria